Paget’s disease of bone (PDB) is a chronic bone disorder that causes bones to grow larger and become weaker than normal. The disease usually affects just one or a few bones, and it most commonly affects the pelvis, skull, spine, and legs.
PDB is caused by a problem with the way that bones remodel. Bone remodeling is a process in which old bone is broken down and replaced with new bone. In PDB, the bone remodeling process is not working properly, which leads to the growth of abnormal bone.
The exact cause of PDB is unknown, but it is thought to be caused by a combination of genetic and environmental factors. PDB is more common in older people and in people who have a family history of the disease.
The symptoms of PDB can vary depending on the bones that are affected. Some people with PDB have no symptoms at all, while others may experience pain, swelling, and deformities in the affected bones. In some cases, PDB can lead to fractures, hearing loss, and nerve damage.
There is no cure for PDB, but there are treatments that can help to manage the symptoms and prevent complications. Treatment options include:
- Bisphosphonate medications: Bisphosphonate medications can help to slow the bone remodeling process and reduce the risk of fractures.
- Surgery: Surgery may be necessary to repair fractures or to remove damaged bone.
- Physical therapy: Physical therapy can help to strengthen the muscles around the affected bones and improve range of motion.
If you have Paget’s disease of bone, it is important to work with your doctor to develop a treatment plan that is right for you. With proper management, most people with PDB can live long and healthy lives.